NOS3 and type 2 diabetes mellitus: Genetic studies and investigations of molecular pathways have revealed that miR-143-3p regulates the ANGPTL8 transcript and protein expression levels50, that the prevalence of T2DM and impaired glucose tolerance is greater in subjects with the R59W ANGPTL8 variant51, and that the concomitant presence of CETP B1, NOS3 T and ANGPTL8 T alleles augments the risk of CVD and T2DM37.