Anle138b is a diphenylpyrazole that reduces aSyn aggregation in various models of PD18,22 and MSA23, aggregation of amyloid beta (AB) in AB dependent mouse models of AD24 and aggregation of tau in tau-dependent mouse models of AD25,26, as well as aSyn spreading in a PD mouse model18. Here, MAPT is linked to Parkinson disease.