R-CA model, R-CA score, LDCA, and Catot/Caion 2 h after RCA-ALSS therapy were positively correlated with disease severity rated by MELD score in derivation and validation cohorts and among patients with or without liver cirrhosis with all the p < 0.01 (Fig. 6, Table 10). This evidence concerns the gene ALMS1 and cirrhosis of liver.