In conclusion, our research unveiled that circ-GLI1 interacted with p70S6K2 to boost GLI1 and β-catenin proteins, so as to activate Hedgehog/GLI1 and Wnt/β-catenin pathways and therefore enhance MYC-activated Cyr61 expression, leading to accelerated metastasis in melanoma. Here, GLI1 is linked to melanoma.