GLI1 and melanoma: Furthermore, it was proven that activation of Wnt/β-catenin pathway could increase the levels of p-GSK3β (Ser9), MYC and Cyr61, while MYC overexpression elevated the levels of MYC and Cyr61 in melanoma cells with circ-GLI1 silence (Fig. 7h, Supplementary Fig. 4d).