Increased expression of the rate limiting enzymes in de novo ATP synthesis (ADSS: adenylosuccinate synthase and ADSL: adenylosuccinate lyase) or de novo pyrimidine synthesis (DHODH: dihydroorotate dehydrogenase and CAD: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) were not associated with decreased survival in patients with newly diagnosed IDH wild type glioma (Fig. 7e). This evidence concerns the gene CAD and central nervous system cancer.