PRKDC and lung cancer: To validate the specificity of the synthetic lethal interaction between anti-miR-1193 and DNA-PKcs deficiency, anti-miR-1193 was transfected into several different human cell lines, including hepatocarcinoma cell lines (HepG2 and Huh7), a lung cancer cell line (A549), a noncancerous cell line (epithelial RPE-1) and fibroblasts.