Similarly as in the putamen, RTP801, SV2A, PSD-95, P-Ser473-Akt, and P-Ser235/236-S6 were highly enriched in the synaptosomal compartment (Supplementary Fig. S2, Enrichment and Supplementary Fig. S3), although no differences in RTP801 levels were observed neither in homogenates (Supplementary Fig. S2, Homogenates) nor in synaptosomes (Supplementary Fig. S3) between HD and non-affected individuals. The gene discussed is RPS6; the disease is Huntington disease.