Indeed, regulatory regions near MEL-specific genes such as SOX10 are accessible in human lines in the MEL state (MM001, MM011, MM031, MM034, MM052, MM057, MM074, MM087, MM118, MM122, and MM164), whereas they are closed in MES melanoma lines (MM029, MM099, MM116, MM163, and MM165) (Fig. 1B). The gene discussed is SOX10; the disease is melanoma.