This classification of melanoma samples was reflected in their accessibility at known MEL and MES regulatory regions such as the intronic enhancer of MLANA, a MEL-specific gene involved in melanosome biogenesis (De Mazière et al. 2002), and an enhancer upstream of MMP3, a gene that increases metastatic potential in melanoma cell lines (Fig. 1E; Shoshan et al. 2016). Here, MMP3 is linked to melanoma.