Altogether, these data suggest a Core Regulatory Complex (CoRC) (Arendt et al. 2016) of SOX10, TFAP2A, MITF, and RUNX factors in regulating melanoma MEL enhancers, encoded by a mixed enhancer model (Long et al. 2016), with high flexibility in the combination of binding sites for these four TFs, but with some rigidity (or hierarchy) in the code as at least one SOX10 dimer site is required. This evidence concerns the gene MITF and melanoma.