By designing DeepMEL, a multiclass, multilabel neural network trained on melanoma human regulatory topics of coaccessible regions, and by using the model interpretation tool DeepExplainer and our newly developed motif scoring scheme (Lundberg and Lee 2017; Lundberg et al. 2020), we were able to perform a thorough and unsupervised analysis of important TF binding sites in melanoma enhancers. Here, TF is linked to melanoma.