Among the most discussed features of SARS-CoV-2, its functional receptor, the aminopeptidase ACE2 (human ACE2), plays a central role, being overly expressed in patients with cardiovascular disease.17 Indeed, the viral infection of the cells, through the binding of ACE2, may set off direct myocardial damage, as it was demonstrated during the SARS outbreak.18 ACE2 expression in the heart is an essential regulator of function, and ACE2 knockout models are inclined to develop severe left ventricular dysfunction. This evidence concerns the gene ACE2 and viral infectious disease.