IL18RAP expression is upregulated in NK and T cells in response to IFN-alpha and IL-12.30IL18RAP was found to be significantly upregulated (adjusted p=5.5 × 10–78) in NK cells in single-cell RNA-seq RA synovium data from Stephenson et al. 31 Similarly, in a second single-cell RNA-seq study of RA synovium,32IL18RAP shows increased expression in synovial tissue T cell populations. The gene discussed is IL18RAP; the disease is rheumatoid arthritis.