IL18RAP and rheumatoid arthritis: In the replication data set, we observed a significant eQTL association (p=5.8×10–11) between multiple SNPs across the IL18RAP locus and IL18RAP expression measured by RNA-seq of whole blood samples in patients with early RA (figure 3A, B), thus confirming that IL18RAP genetic polymorphisms regulate expression of IL18RAP in peripheral blood in patients with early RA.