We also conducted a meta-analysis between an important single nucleotide polymorphism (SNP) of COX-2 gene and CRC risk, and found that the COX-2 rs689466 polymorphism is not associated with CRC risk (G vs. A: OR = 1.06 (95% CI 0.94–1.19), p = 0.363, Fig. 3; GG + AG vs. AA 1.08 (0.95–1.24), p = 0.237; GG vs. AG + AA 1.06 (0.84–1.32), p = 0.627; GG vs. AA 1.10 (0.84–1.44), p = 0.478; GA vs. AA 1.07 (0.95–1.21), p = 0.453; Table 2). The gene discussed is PTGS2; the disease is colorectal carcinoma.