Although our results suggested that COX-2 rs689466 polymorphism was not associated with a higher CRC risk in the overall population, subgroup analysis of ethnicity showed that COX-2 rs689466 polymorphism was associated with increased CRC risk in Caucasians, but not in Asians, suggesting different racial inheritance for Caucasians and Asians. This evidence concerns the gene PTGS2 and colorectal carcinoma.