INS and type 2 diabetes mellitus: Giebelstein et al. [101] found a higher abundance of glycolytic proteins, such as enzymes encoded by GAPDH, PGAM2, ENO3, and PKM2, in obese individuals with and without T2D, while mitochondrial proteins (encoded by ECH1, GBAS, HADHB, and HES1) were downregulated in skeletal muscle from these insulin-resistant individuals (Figure 3).