In yet another study performed on plasma samples from metastatic prostate cancer patients, caveolin-1 (CAV1) was found on 5–10% of large EV (1–10 μm) isolated by filtration, but with a size profile similar to the 10,000 g pellet, whereas it was barely detectable in healthy controls [120]. Here, CAV1 is linked to metastatic prostate carcinoma.