When we excluded one SNP (rs174602) from the FADS2 instruments that was reported to be associated with FADS1 expression [43], the results did not change (Supplemental Table S10) When we included only genome-wide significant hits outside from FADS for D5D, we still observed positive total effect on T2DM (1.04 [0.99–1.08]) and CAD (1.04 [0.98–1.11]), although not significant. Here, FADS1 is linked to coronary artery disorder.