Finally, when we excluded instruments from FADS2 that are in LD with FADS1-SNPs to rule out confounding by LD (Supplemental Figure S13), we observed considerably stronger positive total effect of D6D on T2DM (1.12 [1.06–1.18]) and CAD (1.12 [1.04–1.21]) (Table 3). This evidence concerns the gene FADS1 and type 2 diabetes mellitus.