The antitumour effect of silibinin may correlate with anti-angiogenic mechanisms mediated by the upregulation of angiogenic inhibitors, ANG-2 and TIE-2, and decreasing the production of tumour-associated macrophages and cytokines that are associated with the inhibition of NF-κB and STAT3 phosphorylation [136]. This evidence concerns the gene STAT3 and neoplasm.