Regardless of the definition used, both MHO-IRes and MHO-MetS patients showed a favorable metabolic profile compared to MUO; lower BMI z-score, WC and WtHR (although not statistically significant for MHO-MetS), lower mean systolic and diastolic blood pressure, lower fasting plasma insulin, glycaemia and triglycerides (although not statistically significant for MHO-IRes), as well as higher HDL cholesterol. Here, INS is linked to metabolic syndrome.