Based on transcriptome analysis, activated microglia isolated from seven-week-old Npc1−/− cerebellum more closely resemble those from the Alzheimer disease mouse model (rPearson = 0.55, p < 0.001) than the amyotrophic lateral sclerosis mouse model (rPearson = −0.48, p < 0.001) when compared to their respective controls (Figure S2D). The gene discussed is NPC1; the disease is Alzheimer disease.