To take advantage of this effect, Zhang and colleagues formulated NPs useful for the treatment of breast cancer, able to simultaneously deliver Doxorubicin (DOX), Low-Molecular-Weight Heparin (LMWH), which can inhibit the interaction of angiogenic factors such as Vascular Endothelial Growth Factor (VEGF), and ATRA [137]. This evidence concerns the gene VEGFA and breast cancer.