The following year MPN-associated mutations, such as DNMT3A, TET2, and ASXL1, were found in CH in healthy individuals [10,11,12] and, surprisingly, a study with increased sensitivity for detection of very small clones revealed that mutations in the genes for DNMT3A and TET2 were nearly ubiquitous in individuals above the age of 50 [13]. Here, DNMT3A is linked to myeloproliferative neoplasm.