It has been suggested that the genetic background with the 46/1 haplotype might form a predisposition for the development of the JAK2V617F phenotype [104,105], and other studies have found that an 8-base pair deletion in TERT [106] was associated with the presence of CH and that TET2, but not DNMT3A, mutations exhibited familial aggregation [107]. This evidence concerns the gene DNMT3A and cyclic hematopoiesis.