The mutation was subsequently found to be present in around 50% of ET and PMF patients and in approximately 97% of PV patients [28,29], whereas it was only occasionally identified in myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), and refractory anemia with ringed sideroblasts with marked thrombocytosis (RARS-T) [30]. The gene discussed is RARS1; the disease is acute myeloid leukemia.