At the age of 20 days (without the manifestations of AD-like pathology), the expression of six genes (Camk2b, Gadd45g, Map3k5, Mapk14, Mapk8ip2, and Mapkapk3) was higher and Map3k7 gene expression was lower in OXYS rats than in Wistar rats (Figure 1a). This evidence concerns the gene MAPK8IP2 and Alzheimer disease.