They generated tamoxifen-inducible and VSMC-specific RhoBTB1 transgenic mice (S-RhoBTB1) and found that Rho-BTB1 expression was reduced in S-P467L mice, whereas S-P467L/S-RhoBTB1 mice exhibited the restoration of RhoBTB1 expression and improvement of vasocontraction in VSMCs, which was accompanied by the reduced PDE5 activity, leading to the attenuation of hypertension. Here, PDE5A is linked to hypertensive disorder.