PDE5A and Hypertension: They generated tamoxifen-inducible and VSMC-specific RhoBTB1 transgenic mice (S-RhoBTB1) and found that Rho-BTB1 expression was reduced in S-P467L mice, whereas S-P467L/S-RhoBTB1 mice exhibited the restoration of RhoBTB1 expression and improvement of vasocontraction in VSMCs, which was accompanied by the reduced PDE5 activity, leading to the attenuation of hypertension.