CUL3 and pseudohypoaldosteronism type 2: Till date, mutations in four genes are known to cause PHAII, which include serine-threonine kinase with-no-lysine (WNK) 1 and WNK4 and Cullin 3 (CUL3) and Kelch-like 3 (KLHL3), the components of the cullin-RING ubiquitin ligase (CRL) complex [3,28,29].