The observation that TCDD induced CYP1A1 but did not inhibit GBM invasion and that OME inhibited invasion but did not induce or minimally induced other AhR-responsive genes (CYP1A1, CYP1B1, and TiPARP) (Figure S1) suggests that OME is a SAhRM that selectively modulates AhR-mediated responses. The gene discussed is CYP1A1; the disease is glioblastoma.