Manfroi in a recent work demonstrated that in a significant fraction of DLBCL patients, tumor cells are able to recruit APRIL producing neutrophils through the release of CXCL8 in both GC and non-GC DLBCL subtypes that in turn induce DNA methylation and acetylation, crucial in DLBCL progression [57]. The gene discussed is CXCL8; the disease is neoplasm.