CXCL8 and neoplasm: The N2 neutrophils are characterized by upregulation of the chemokines CCL2, CCL3, CCL4, CCL8, CCL12, and CCL17, and CXCL1, CXCL2, IL-8/CXCL8 and CXCL16 and are involved in tumor growth, invasion, metastasis, angiogenesis and immunosuppression [46].