TNF and neoplasm: Cells resident in tumor inflammatory microenvironment, include macrophages, neutrophils, mast cells, myeloid derived suppressor cells, dendritic cells, natural killer cells, and T and B lymphocytes capable of producing an assorted array of cytokines, cytotoxic mediators, including reactive oxygen species, serine and cysteine proteases, matrix metalloproteinases (MMPs), membrane-perforating agents, and soluble mediators of cell killing, such as tumor necrosis factor alpha (TNF-α), interleukins and interferons (IFNs) [19,20].