Our Western blot assay results demonstrate that while PRMT5 protein is 2.3-Fold (p < 0.01) overexpressed in the KRAS WT CRC cells when compared to normal CCD 841 CoN colon cells, the KRAS mutant CRC cells show a more substantial 11.3-Fold (p < 0.05) overexpression of PRMT5 protein. The gene discussed is PRMT5; the disease is colorectal carcinoma.