PRMT5 and colorectal carcinoma: More significantly, our Western blot assay results display that when comparing the PRMT5 expression of the KRAS mutant CRC cells to the KRAS WT CRC cells, the KRAS mutant CRC cells show a further 4.8-Fold (p < 0.01) overexpression of PRMT5 at the translational level (Figure 3).