Our results show that BMPRII is strongly bound to BMPRI following treatment with BMP-2, but this interaction was completely abolished in the presence of TrkB (Figure 5E), but not by the TrkB KD mutant (Figure 5F), indicating that TrkB kinase activity is required for it to interfere with BMP-mediated tumor suppression. Here, NTRK2 is linked to neoplasm.