REG1A and Cowden disease: For example, they showed upregulation during intestinal inflammation in infectious colitis [40]; were found to be up-regulated in metaplastic Paneth cells in both un-inflamed and inflamed colonic mucosa from IBD patients, with increased expression during inflammation [41,42]; and REG1A/REG1B was also found to be widely expressed in a newly identified T-cell subtype isolated from CD patients using a single-cell analysis of intestinal T cells [43].