We finally investigated whether maternal HFD and exposure to grape juice during pregnancy and lactation affected receptors in the offspring′s mammary glands that are commonly expressed in breast cancers, serve as treatment targets (ERα, HER2) and are linked to adipose differentiation and glucose homeostasis (PPARγ) and insulin and insulin-like growth factor signaling (IRS1). The gene discussed is ESR1; the disease is breast carcinoma.