Since EnR stress in the HFD offspring might have, for example, led to NLRP3-inflammasome activation or a release of inflammatory mediators, and maternal obesity is known to increase inflammatory markers in the offspring [71,72], future studies should explore whether maternal grape juice might counteract increased inflammation in the HFD offspring. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.