RIGI and hepatocellular carcinoma: Xu et al. used an HEV3–Kernow replicon system in Huh7.5 cells (a RIG-I-defective hepatoma cell line) to show that the ectopic overexpression of RIG-I delivered by a lentivirus vector strongly reduced HEV3–Kernow replicon luciferase activity 48 h after transduction [53].