An RT 2 profiler PCR array study that compared the host immune responses of rhesus macaques to HEV1–Sar55 and HEV3–JN837481 infections showed that IFIT1, IFIT3, IRF1, IRF7, and ISG15 productions increased, while the synthesis of IFITM1, IFNAR1, IRF2, IRF3, and IRF5 increased only in response to HEV3–JN837481 [50]. This evidence concerns the gene IRF7 and infection.