The expression of the TLR3, TLR5, and TLR6 genes in the liver tissue of infected rhesus macaques was downregulated in the early phase of HEV1 Sar-55 and HEV3-JN83748 infections, while TLR3 gene expression was only upregulated at peak infection and declined during HEV3 infection [50]. This evidence concerns the gene TLR6 and infection.