LGALS2 and colorectal cancer: Indeed, the role of galectin-2 might be more complex as its circulating levels were reported to increase moderately in patients with breast cancer (median 1.2-fold increase) and colorectal cancer (median 1.9-fold increase) [33] whereas galectin-2 expression was decreased in the placental tissue of patients with preeclampsia and spontaneous abortions [130,131].