On a background of patients’ heterogeneity, stimulation with two different TLR-7 agonists resulted in a significant reduction of the frequency of IFN-α-producing pDCs in MM (R848 p = 0.004; imiquimod (IMQ) p = 0.02) (Table 2 and Figure 1B). This evidence concerns the gene TLR7 and Miyoshi myopathy.