In addition, the I-IFN response is fine-tuned by a set of surface interferon inhibitory receptors, such as the immunoglobulin-like transcript 7 (ILT-7) and the type II C-type lectin BDCA-2 [74,75], and their physiological ligands have been identified on tumor cells [76,77]. The gene discussed is CLEC4C; the disease is neoplasm.