An inverted cytokine receptor was engineered on T cells, which had the exodomain of IL-4 and the endodomain of IL-7; the results showed that the inverted cytokine receptor could convert suppressive signals into T cell proliferative signals in prostate stem cell antigen (PSCA)-specific CAR-T cells and caused enhanced anti-tumor immunity in prostate cancer models [134]. Here, IL7 is linked to neoplasm.