Strikingly, malignant mesothelioma patients with high levels of SDC-1 (>19.28 ng/mL) and VEGF (>0.7 ng/mL) have significantly worse prognosis in comparison to the patients with low levels of SDC-1 (<19.28 ng/mL) and VEGF (<0.7 ng/mL). The gene discussed is VEGFA; the disease is malignant mesothelioma.