In order to determine the prognostic value of pleural effusion derived Angiopoietin-1, HGF, MMP-7, Osteopontin, TIMP-1, Galectin, Mesothelin, NRG1-b1, SDC-1 and VEGF, we divided patients in two groups depending on the established cut-off value for all analytes. Here, SPP1 is linked to Pleural effusion.