Previous studies showed that, Calretinin, Wilms tumor protein 1 (WT-1), HBME-1, D2-40 (podoplanin), Carcinoembryonic antigen (CEA), Napsin-A and Thyroid transcription factor 1 (TTF-1) are immunocytochemical indicators for distinguishing malignant mesothelioma from lung adenocarcinoma [3,34,35]. The gene discussed is NKX2-1; the disease is malignant mesothelioma.