In order to describe the diagnostic power of pleural effusion derived Angiopoietin-1, HGF, MMP-7, Osteopontin, TIMP-1, Galectin, Mesothelin, NRG1-b1, Syndecan-1 and VEGF, we compared the expression level of these 10 angiogenesis related biomarkers in pleural effusion from malignant pleural mesothelioma patients (n = 42) and benign samples (n = 40). The gene discussed is MSLN; the disease is malignant pleural mesothelioma.