In order to describe the diagnostic power of pleural effusion derived Angiopoietin-1, HGF, MMP-7, Osteopontin, TIMP-1, Galectin, Mesothelin, NRG1-b1, Syndecan-1 and VEGF, we compared the expression level of these 10 angiogenesis related biomarkers in pleural effusion from malignant pleural mesothelioma patients (n = 42) and benign samples (n = 40). This evidence concerns the gene TIMP1 and malignant pleural mesothelioma.