In addition to seeding and intracellular propagation of TDP-43 aggregations between cells in vitro and in vivo, different types of the TDP-43 aggregates in ALS and frontotemporal lobar degeneration (FTLD) diseased brains have been identified [41,42,43,44,45]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.