So far, more than 50 potentially causative or ALS-modifying genes have been identified that are mainly involved in two cellular processes: RNA metabolism (TDP-43, FUS, MATR3, hnRNPA1, hnRNPA2B1, TIA1, etc.)and quality control of protein metabolism (VCP, UBQLN2, SQSTM1, OPTN, etc.)[7,10,11,12,13,14,15,16,17,18,19,20,21]. The gene discussed is VCP; the disease is amyotrophic lateral sclerosis.