In A375 human malignant melanoma cells, arbutin at high concentration (1 mM) up-regulated 88 genes and down-regulated 236 genes, including genes (AKT1, CLECSF7, FGFR3, and LRP6) controlling cell cycle progression [21], hence, suggesting that it may act similarly on neutrophils. This evidence concerns the gene CLEC4C and melanoma.