IL10 and autoimmune lymphoproliferative syndrome: This incidence is more marginally increased in diseases with a predominance of immune dysregulations such as autoimmune lymphoproliferative syndrome (ALPS) or interleukin-10 receptor deficiency syndrome; it is intermediately higher with PIDs which predominantly involve antibody deficiencies, ranging from about 10% with common variable immunodeficiencies to about 25% with activated phosphoinositide 3-kinase delta syndrome (APDS) [4].