ALPS is caused by variants in many genes involved in apoptosis, particularly by an inherited variant in TNFRSF6. This gene encodes the Fas cell surface death receptor, a transmembrane protein belonging to the TNF-receptor superfamily promoting cell death signalling via a complex formed by the interaction between its cell-death domain, caspase 8 and caspase 10. This evidence concerns the gene FAS and autoimmune lymphoproliferative syndrome.