RHOC and breast cancer: The high expression of miR-10b in metastatic BC is induced by the transcription factor Twist, which binds directly to the putative promoter of mir-10b and leads to the inhibition of translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RHOC. Thus, Twist-mediated miR-10b upregulation induces local invasion and migration of BCCs [68].