Activation markers, such as integrin Mac-1 (CD11b/CD18), L-selectin (CD62L), CBRM1/5, ICAM-1 (CD54), PD-L1 (CD274), PSGL-1 (CD162), FcγRII (CD32), CD16, CD44, and CD69, were shown to be upregulated on circulating or sputum granulocytes from asthma patients [8,9]. The gene discussed is CD274; the disease is asthma.