In addition to excessive exposure to ultraviolet radiation (UVR), post-inflammatory melanoderma occurring in healing after inflammation [1,2,3] and involuntary activation of alpha-melanocyte stimulating hormone (α-MSH) receptors by adrenocorticotropic hormone (ACTH) associated to Addison’s disease may result in hyperpigmentation [3,4]. This evidence concerns the gene POMC and primary adrenal insufficiency.