Specifically, we find comparable CP-AMPAR increases (both expression and function) whether obesity-prone males are maintained on JF for 10 days or 30 days, and have found that even when food intake and weight gain are the same in obesity-prone vs. obesity-resistant rats CP-AMPAR transmission is increased in obesity-prone but not obesity-resistant males [13]. The gene discussed is CP; the disease is obesity due to melanocortin 4 receptor deficiency.