Here, we report that Zip14 upregulation and altered metal‐ion homeostasis are likely to underlie the development of cachexia in the Bard1‐deficient, orthotopic mouse model of breast cancer metastasis, a finding that could have clinical implications for triple‐negative breast cancers with BRCA1/BARD1 dysfunction. This evidence concerns the gene BRCA1 and breast carcinoma.