CXCL8 and cancer: CXCL8 also integrates with multiple intracellular signalling pathways to produce coordinated effects.PI3K/Akt pathway is a major downstream signaling pathway of IL-8 inducing cancer cell migration, invasion, and metastasis [41,42].Numerous studies showed that activation of the PI3K/Akt signaling pathway was critical to the development and progression of HCC and could modulate the malignant behavior of HCC [43,44].