CXCL8 mediated tumor progression, occurring primarily through CXC receptor 1 (CXCR1) and CXC receptor 2 (CXCR2),has been identified as a function of the modulation of angiogenesis, immune cell infiltration, cell motility, cell survival, and growth in the microenvironment as well as the regulation of local antitumor immune responses [39]. This evidence concerns the gene CXCL8 and neoplasm.