Huang et al. reported that down regulation of CXCR1 dramatically reduced HCC cell migration, invasion in vitro and lung metastasis in mice model, and HCC patients with positive expression of CXCL8 or CXCR1 had shorter overall survival time and higher recurrence rate compared with those with negative expression [40]. Here, CXCL8 is linked to hepatocellular carcinoma.