Liver IL-1β expression in dual-transgenic tilapia was 3.8-fold lower and 1.4-fold lower than in wild-type tilapia at 3 h and 6 h post-infection, respectively (Fig 6A); muscle IL-1β expression in dual-transgenic tilapia was 2.8-fold lower than in wild-type tilapia at 3 h after injection (Fig 7A). The gene discussed is IL1B; the disease is infection.