Fig 5F demonstrates that the DFO treatment of TfR1 silenced cells does result in higher PEDV infection levels in IPEC-J2 and Vero cells. Given these results, we speculated that higher levels of TfR1 may promote infection in cells normally refractory to PEDV, hence, Caco-2 (Fig 5G and 5H) and HEK 293T (Fig 5I and 5J) cell lines were used. The gene discussed is TFRC; the disease is infection.