During the process of colon cancer metastasis, cancer cell survival in suspension requires lipid raft-associated CD44, and nuclear CD44/acetylated-STAT3 generates cells with properties of CSCs and the epithelial–mesenchymal transition (EMT) phenotype by transcriptional reprogramming, leading to drug resistance, tumor metastasis (TM), and a resulting poor prognosis [18]. This evidence concerns the gene CD44 and malignant colon neoplasm.