With regard to the effect of adrenaline infusion on acute appetite control in obese women, previous studies reported reduced circulating leptin concentrations after 60 minutes of adrenaline infusion (0.010 μg/kg fat free mass/min), suggesting that a decrease in obesity-related leptinemia could stimulate a compensatory appetite response but this was not assessed (Couillard et al., 2002). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.