By using online bioinformatic tools (http://genome.ucsc.edu/; http://bioinfo.life.hust.edu.cn/hTFtarget#!/), STAT3 was predicted to bind the promoter region of NUP98. To test this prediction, we transfected RCC cells with pcDNA.STAT3 that successfully enhanced the expression of STAT3 (Figure 6A,B). This evidence concerns the gene STAT3 and renal cell carcinoma.