NUP98 and renal cell carcinoma: By using online bioinformatic tools (http://genome.ucsc.edu/; http://bioinfo.life.hust.edu.cn/hTFtarget#!/), STAT3 was predicted to bind the promoter region of NUP98. To test this prediction, we transfected RCC cells with pcDNA.STAT3 that successfully enhanced the expression of STAT3 (Figure 6A,B).