INS and Hutchinson-Gilford progeria syndrome: Similarly, whereas HGPS patients have high insulin levels and some have hyperglycemia and low glucose tolerance (Gerhard‐Herman et al., 2012; Gordon, Campbell, et al., 2018; Gordon et al., 2005; Merideth et al., 2008), progeric mice exhibit hypoglycemia, hypoinsulinemia (López‐Mejía et al., 2014; Osorio et al., 2011), and high glucose tolerance (Figure 2b).