LMNA and autosomal dominant disease: This exceptionally rare (prevalence of 1 in 20 million), autosomal dominant disease is caused by a point mutation in exon 11 of the LMNA gene, which provokes the production of progerin, an aberrant form of lamin A. Progerin accumulation in the nuclear envelope causes structural defects, chromatin disorganization, and DNA damage (Dorado & Andrés, 2017; Gordon, Rothman, López‐Otín, & Misteli, 2014).