These findings are consistent with electrical conduction and repolarization abnormalities that can potentially lead to arrhythmias, which have been previously described for 30‐month‐old WT mice, progeric Zmpste24‐deficient mice, HGPS minipigs, and HGPS patients (Dorado et al., 2019; Rivera‐Torres et al., 2016; Signore et al., 2015). Here, ZMPSTE24 is linked to Arrhythmia.