Despite the undeniable lack of power in our study and the necessary caution in drawing conclusions from alterations observed primarily at the GO level, the results obtained in human BAL cells in the context of MS corroborate the molecular signature found in animal studies of EAE.6 In EAE animals, lung-mobilized immune cells attain enhanced mobility through intense gene reprogramming in the lungs, marked by downregulation of their activation program and upregulation of cellular locomotion transcripts, with a pivotal role of Ninjurin 1. This evidence concerns the gene NINJ1 and myeloid sarcoma.