Here, we examined the status of EGFR, HER2, BRAF, KRAS, ALK, MET, NRAS, PIK3CA, RET, and ROS1 in 884 patients with NSCLC who had undergone surgical resection, bronchoscopy biopsy or percutaneous transthoracic biopsy by NGS in our institution. Here, PIK3CA is linked to non-small cell lung carcinoma.