CRP and rheumatoid arthritis: In 2015, Cooles et al. reported no relationship between 25OHD and CRP, ESR, symptom duration, tender joint count (TJC), swollen joint count (SJC), or patients’ global health visual analogue scale (GH-VAS) in a small cohort of 73 RA patients [13], and similarly Neilen et al. found no evidence of low vitamin D in blood donor samples from patients in the pre-RA phase [14].